Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

• 成果类型: Article
• 署名作者: Schwarzer, Martin; Gautam, Umesh Kumar; Makki, Kassem; Lambert, Anne; Brabec, Tomas; Joly, Amelie; Srutkova, Dagmar; Poinsot, Pierre; Novotna, Tereza; Geoffroy, Stephanie; Courtin, Pascal; Hermanova, Petra Petr; Matos, Renata C.; Landry, Jonathan J. M.; Gerard, Celine; Bulteau, Anne-Laure; Hudcovic, Tomas; Kozakova, Hana; Filipp, Dominik; Chapot-Chartier, Marie -Pierre; Sinkora, Marek; Peretti, Noel; Boneca, Ivo Gomperts; Chamaillard, Mathias; Vidal, Hubert; De Vadder, Filipe; Leulier, Francois
• 署名单位: Czech Academy of Sciences; Institute of Microbiology of the Czech Academy of Sciences; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; INRAE; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; CHU Lyon; INRAE; Universite Paris Saclay; AgroParisTech; European Molecular Biology Laboratory (EMBL); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Gothenburg
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-14123
• DOI: 10.1126/science.ade9767
• 发表日期: 2023-02-24
• 页码: 826-833
• 关键词: stem-cell protection; glucose-homeostasis; gut microbiota; factor-i; insulin; peptidoglycan; receptors; roles; liver; igf1

摘要

The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJLsustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.