A Gγ protein regulates alkaline sensitivity in crops

• 成果类型: Article
• 署名作者: Zhang, Huili; Yu, Feifei; Xie, Peng; Sun, Shengyuan; Qiao, Xinhua; Tang, Sanyuan; Chen, Chengxuan; Yang, Sen; Mei, Cuo; Yang, Dekai; Wu, Yaorong; Xia, Ran; Li, Xu; Lu, Jun; Liu, Yuxi; Xie, Xiaowei; Ma, Dongmei; Xu, Xing; Liang, Zhengwei; Feng, Zhonghui; Huang, Xiahe; Yu, Hong; Liu, Guifu; Wang, Yingchun; Li, Jiayang; Zhang, Qifa; Chen, Chang; Ouyang, Yidan; Xie, Qi
• 署名单位: Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Ningxia University; China Agricultural University; Huazhong Agricultural University; Hubei Hongshan Laboratory; Huazhong Agricultural University; Yangzhou University; Yangzhou University; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8447
• DOI: 10.1126/science.ade8416
• 发表日期: 2023-03-24
• 页码: 1204-+
• 关键词: grain-size; gs3; transport; modulate; encodes; SYSTEM; length; acts; h2o2; pip2

摘要

The use of alkaline salt lands for crop production is hindered by a scarcity of knowledge and breeding efforts for plant alkaline tolerance. Through genome association analysis of sorghum, a naturally high-alkaline-tolerant crop, we detected a major locus, Alkaline Tolerance 1 (AT1), specifically related to alkaline-salinity sensitivity. An at1 allele with a carboxyl-terminal truncation increased sensitivity, whereas knockout of AT1 increased tolerance to alkalinity in sorghum, millet, rice, and maize. AT1 encodes an atypical G protein g subunit that affects the phosphorylation of aquaporins to modulate the distribution of hydrogen peroxide (H2O2). These processes appear to protect plants against oxidative stress by alkali. Designing knockouts of AT1 homologs or selecting its natural nonfunctional alleles could improve crop productivity in sodic lands.