The contribution of historical processes to contemporary extinction risk in placental mammals

• 成果类型: Article
• 署名作者: Wilder, Aryn P.; Supple, Megan A.; Subramanian, Ayshwarya; Mudide, Anish; Swofford, Ross; Serres-Armero, Aitor; Steiner, Cynthia; Koepfli, Klaus -Peter; Genereux, Diane P.; Karlsson, Elinor K.; Lindblad-Toh, Kerstin; Marques-Bonet, Tomas; Fuentes, Violeta Munoz; Foley, Kathleen; Meyer, Wynn K.; Ryder, Oliver A.; Shapiro, Beth
• 署名单位: University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz; Howard Hughes Medical Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; ITMO University; University of Massachusetts System; University of Massachusetts Worcester; Uppsala University; ICREA; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Institut Catala de Paleontologia Miquel Crusafont (ICP); Autonomous University of Barcelona; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of Iowa; Lehigh University; University of California System; University of California San Diego
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10278
• DOI: 10.1126/science.abn5856
• 发表日期: 2023-04-28
• 页码: 372-+
• 关键词: inbreeding depression; conservation status; mutation load; genome; inference; rates

摘要

Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of 240 mammals that compose the Zoonomia alignment to evaluate how historical effective population size (Ne) affects heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. We find that species with smaller historical Ne carry a proportionally larger burden of deleterious alleles owing to long-term accumulation and fixation of genetic load and have a higher risk of extinction. This suggests that historical demography can inform contemporary resilience. Models that included genomic data were predictive of species' conservation status, suggesting that, in the absence of adequate census or ecological data, genomic information may provide an initial risk assessment.