Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

• 成果类型: Article
• 署名作者: Zhao, Bingxin; Li, Tengfei; Fan, Zirui; Yang, Yue; Shu, Juan; Yang, Xiaochen; Wang, Xifeng; Luo, Tianyou; Tang, Jiarui; Xiong, Di; Wu, Zhenyi; Li, Bingxuan; Chen, Jie; Shan, Yue; Tomlinson, Chalmer; Zhu, Ziliang; Li, Yun; Stein, Jason L.; Zhu, Hongtu
• 署名单位: University of Pennsylvania; Purdue University System; Purdue University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; Purdue University System; Purdue University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12108
• DOI: 10.1126/science.abn6598
• 发表日期: 2023-06-02
• 页码: 934-+
• 关键词: genome-wide association; aldehyde dehydrogenase; cardiovascular-disease; psychiatric-disorders; cognitive impairment; susceptibility loci; polygenic scores; risk-factors; stress; HEALTH

摘要

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci (P < 6.09 x 10-10) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.