Functional diversification of a wild potato immune receptor at its center of origin

• 成果类型: Article
• 署名作者: Ascurra, Yerisf C. Torres; Zhang, Lisha; Toghani, Amirali; Hua, Chenlei; Rangegowda, Nandeesh Jalahalli; Posbeyikian, Andres; Pai, Hsuan; Lin, Xiao; Wolters, Pieter J.; Wouters, Doret; de Blok, Reinhoud; Steigenga, Niels; Paillart, Maxence J. M.; Visser, Richard G. F.; Kamoun, Sophien; Nuernberger, Thorsten; Vleeshouwers, Vivianne G. A. A.
• 署名单位: Wageningen University & Research; Eberhard Karls University of Tubingen; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Wageningen University & Research; University of Johannesburg; Chinese Academy of Sciences; Institute of Microbiology, CAS; Purdue University System; Purdue University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10252
• DOI: 10.1126/science.adg5261
• 发表日期: 2023-08-25
• 页码: 891-+
• 关键词: phytophthora-infestans; oligopeptide elicitor; pattern; resistance; complex; sequence

摘要

Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.