Hypothalamic control of innate social behaviors

• 成果类型: Review
• 署名作者: Long Mei; Osakada, Takuya; Lin, Dayu
• 署名单位: New York University; NYU Langone Medical Center; NYU Langone Medical Center; New York University; NYU Langone Medical Center; New York University; New York University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12698
• DOI: 10.1126/science.adh8489
• 发表日期: 2023-10-27
• 页码: 400-+
• 关键词: medial preoptic area; ventral premammillary nucleus; phaseolus-vulgaris-leukoagglutinin; midbrain central gray; ventromedial hypothalamus; periaqueductal gray; estrogen-receptor; partner preference; sexual receptivity; maternal-behavior

摘要

Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals and species survival and thus are supported by hardwired neural circuits. The reproductive behavior control column (RBCC), which comprises the medial preoptic nucleus (MPN), the ventrolateral part of the ventromedial hypothalamus (VMHvl), and the ventral premammillary nucleus (PMv), is essential for all social behaviors. The RBCC integrates diverse hormonal and metabolic cues and adjusts an animal's physical activity, hence the chance of social encounters. The RBCC further engages the mesolimbic dopamine system to maintain social interest and reinforces cues and actions that are time-locked with social behaviors. We propose that the RBCC and brainstem form a dual-control system for generating moment-to-moment social actions. This Review summarizes recent progress regarding the identities of RBCC cells and their pathways that drive different aspects of social behaviors.