Neurocircuits for motivation

• 成果类型: Review
• 署名作者: Stuber, Garret D.
• 署名单位: University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10031
• DOI: 10.1126/science.adh8287
• 发表日期: 2023-10-27
• 页码: 395-399
• 关键词: lateral hypothalamus; circuit architecture; dopamine neurons; gaba neurons; reward; habenula; inputs; INFORMATION; activation; responses

摘要

The nervous system coordinates various motivated behaviors such as feeding, drinking, and escape to promote survival and evolutionary fitness. Although the precise behavioral repertoires required for distinct motivated behaviors are diverse, common features such as approach or avoidance suggest that common brain substrates are required for a wide range of motivated behaviors. In this Review, I describe a framework by which neural circuits specified for some innate drives regulate the activity of ventral tegmental area (VTA) dopamine neurons to reinforce ongoing or planned actions to fulfill motivational demands. This framework may explain why signaling from VTA dopamine neurons is ubiquitously involved in many types of diverse volitional motivated actions, as well as how sensory and interoceptive cues can initiate specific goal-directed actions.