Pregnancy-responsive pools of adult neural stem cells for transient neurogenesis in mothers

• 成果类型: Article
• 署名作者: Chaker, Zayna; Segalada, Corina; Kretz, Jonas A.; Acar, Ilhan E.; Delgado, Ana C.; Crotet, Valerie; Moor, Andreas E.; Doetsch, Fiona
• 署名单位: University of Basel; Swiss Federal Institutes of Technology Domain; ETH Zurich
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9235
• DOI: 10.1126/science.abo5199
• 发表日期: 2023-11-24
• 页码: 958-963
• 关键词: olfactory-bulb; stimulated neurogenesis; plasticity; neurons; brain; forebrain; death

摘要

Adult neural stem cells (NSCs) contribute to lifelong brain plasticity. In the adult mouse ventricular-subventricular zone, NSCs are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb (OB) interneurons. Here, we show that multiple regionally distinct NSCs, including domains that are usually quiescent, are recruited on different gestation days during pregnancy. Synchronized activation of these adult NSC pools generates transient waves of short-lived OB interneurons, especially in layers with less neurogenesis under homeostasis. Using spatial transcriptomics, we identified molecular markers of pregnancy-associated interneurons and showed that some subsets are temporarily needed for own pup recognition. Thus, pregnancy triggers transient yet behaviorally relevant neurogenesis, highlighting the physiological relevance of adult stem cell heterogeneity.