Protein design meets biosecurity
成果类型：
Editorial Material
署名作者：
Baker, David; Church, George
署名单位：
University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Harvard University; Harvard Medical School
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-10221
DOI：
10.1126/science.ado1671
发表日期：
2024-01-26
页码：
349-349
关键词：
摘要：
The power and accuracy of computational protein design have been increasing rapidly with the incorporation of artificial intelligence (AI) approaches. This promises to transform biotechnology, enabling advances across sustainability and medicine. DNA synthesis plays a critical role in materializing designed proteins. However, as with all major revolutionary changes, this technology is vulnerable to misuse and the production of dangerous biological agents. To enable the full benefits of this revolution while mitigating risks that may emerge, all synthetic gene sequence and synthesis data should be collected and stored in repositories that are only queried in emergencies to ensure that protein design proceeds in a safe, secure, and trustworthy manner.