Nitrogen cuts in during C-C cross-coupling
成果类型：
Editorial Material
署名作者：
Shaughnessy, Kevin H.
署名单位：
University of Alabama System; University of Alabama Tuscaloosa
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-12672
DOI：
10.1126/science.ado0068
发表日期：
2024-03-01
页码：
958-958
关键词：
摘要：
A catalyst system diverts traditional C-C bond coupling into desired C-N bond formation Transition metal-catalyzed cross-coupling, which creates a bond between two target molecules, is a workhorse method for synthesizing pharmaceuticals, agricultural chemicals, electronic materials, and other fine chemicals ( 1 ). The generation of biaryl compounds by the Suzuki-Miyaura (SM) coupling ( 2 ) and of aryl amines by the Buchwald-Hartwig (BH) coupling ( 3 ) reactions are two of the most used transformations in the pharmaceutical industry ( 4 ). Their prevalence has resulted in biaryl and arylamine structures as common motifs in drug candidates. New methods to prepare these structures will expand the chemical space that can be accessed in cross-coupling reactions. On page 1019 of this issue, Onnuch et al. ( 5 ) report a palladium-catalyzed aminative SM coupling reaction in which the traditional SM coupling of an aryl (pseudo)halide and an arylboron compound is interrupted by the insertion of nitrogen. This results in the formation of two new C-N bonds in one reaction.