Edible electronics to treat the brain
成果类型：
Editorial Material
署名作者：
Ramadi, Khalil
署名单位：
New York University; New York University Tandon School of Engineering; New York University; New York University; NYU Langone Medical Center
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-13466
DOI：
10.1126/science.ado4543
发表日期：
2024-04-05
页码：
42-42
关键词：
摘要：
Ingestible electronic pills can be used for targeted noninvasive neuromodulation If you stroll by the Hershey's chocolate store in Times Square, you may be very tempted to enter. The smell of chocolate permeates the air, driven by exhaust fans that pump air onto the sidewalk. A similar urge might strike if you walk by your neighborhood bakery. Such is the power of neuromodulation. We are constantly exposed to external stimuli that activate innate and learned neural circuits that drive behavior. And yet, despite all these instances, state-of-the-art clinical neuromodulation technologies remain relatively crude. At one extreme, there are techniques such as deep brain stimulation (DBS), which can activate specific neural nodes but requires invasive neurosurgery to implant. At the other, there are noninvasive methods such as auricular vagus nerve stimulation, but this method indiscriminately activates diverse vagal neurons. There remains a fundamental trade-off between invasiveness and specificity.