Exceptionally long-lived nuclear RNAs

• 成果类型: Editorial Material
• 署名作者: Lawrence, Jeanne; Hall, Lisa
• 署名单位: University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11217
• DOI: 10.1126/science.ado5751
• 发表日期: 2024-04-05
• 页码: 31-32
• 关键词: ARCHITECTURE

摘要

RNA has come a long way from a simple messenger or translator of canonical genic information during the production of proteins. A plethora of new types of noncoding RNAs have been discovered, including thousands of long noncoding RNAs (lncRNAs), many of which have no identified functions ( 1 , 2 ). Throughout this RNA revolution, one property of RNA has been thought to be constant: RNAs are short-lived molecules that turn over, unlike DNA, which is much more stable. On page 53 of this issue, Zocher et al. ( 3 ) challenge that paradigm by showing that newly synthesized RNA labeled with 5-ethynyl uridine (EU) in early postnatal mice was still present in many brain cells 2 years later. The complex pattern of when and which cells are labeled suggests that EU that is incorporated into RNA in neural progenitor cells (NPCs) frequently remains in adult neurons. This suggests that a diversity of long and repeat-rich RNAs, collectively called long-lived RNAs (LL-RNAs), can be stable fixtures in postmitotic and quiescent neural cells.