A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution
成果类型：
Article
署名作者：
Shapson-Coe, Alexander; Januszewski, Michal; Berger, Daniel R.; Pope, Art; Wu, Yuelong; Blakely, Tim; Schalek, Richard L.; Li, Peter H.; Wang, Shuohong; Maitin-Shepard, Jeremy; Karlupia, Neha; Dorkenwald, Sven; Sjostedt, Evelina; Leavitt, Laramie; Lee, Dongil; Troidl, Jakob; Collman, Forrest; Bailey, Luke; Fitzmaurice, Angerica; Kar, Rohin; Field, Benjamin; Wu, Hank; Wagner-Carena, Julian; Aley, David; Lau, Joanna; Lin, Zudi; Wei, Donglai; Pfister, Hanspeter; Peleg, Adi; Jain, Viren; Lichtman, Jeff W.
署名单位：
Harvard University; University of London; Queen Mary University London; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated; Princeton University; Princeton University; Korea Advanced Institute of Science & Technology (KAIST); Harvard University; Allen Institute for Brain Science; Northeastern University; Boston College; Alphabet Inc.; Google Incorporated
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-13656
DOI：
10.1126/science.adk4858
发表日期：
2024-05-10
关键词：
tissue
volume
brain
astrocytes
microscopy
anatomy
network
atlas
cells
摘要：
To fully understand how the human brain works, knowledge of its structure at high resolution is needed. Presented here is a computationally intensive reconstruction of the ultrastructure of a cubic millimeter of human temporal cortex that was surgically removed to gain access to an underlying epileptic focus. It contains about 57,000 cells, about 230 millimeters of blood vessels, and about 150 million synapses and comprises 1.4 petabytes. Our analysis showed that glia outnumber neurons 2:1, oligodendrocytes were the most common cell, deep layer excitatory neurons could be classified on the basis of dendritic orientation, and among thousands of weak connections to each neuron, there exist rare powerful axonal inputs of up to 50 synapses. Further studies using this resource may bring valuable insights into the mysteries of the human brain.