Fetal exposure to the Ukraine famine of 1932-1933 and adult type 2 diabetes mellitus

• 成果类型: Article
• 署名作者: Lumey, L. H.; Li, Chihua; Khalangot, Mykola; Levchuk, Nataliia; Wolowyna, Oleh
• 署名单位: Columbia University; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); University of Macau; University of Michigan System; University of Michigan; Johns Hopkins University; National Academy of Medical Sciences of Ukraine; V. P. Komissarenko Institute of Endocrinology & Metabolism of the National Academy of Medical Science of Ukraine; Shupyk National Healthcare University of Ukraine; National Academy of Sciences Ukraine; Ptoukha Institute for Demography & Social Studies of the National Academy of Sciences of Ukraine; Max Planck Society; University of North Carolina; University of North Carolina Chapel Hill
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13230
• DOI: 10.1126/science.adn4614
• 发表日期: 2024-08-09
• 页码: 667-671
• 关键词: prenatal exposure; chinese famine; early-life; losses; AGE

摘要

The short-term impact of famines on death and disease is well documented, but estimating their potential long-term impact is difficult. We used the setting of the man-made Ukrainian Holodomor famine of 1932-1933 to examine the relation between prenatal famine and adult type 2 diabetes mellitus (T2DM). This ecological study included 128,225 T2DM cases diagnosed from 2000 to 2008 among 10,186,016 male and female Ukrainians born from 1930 to 1938. Individuals who were born in the first half-year of 1934, and hence exposed in early gestation to the mid-1933 peak famine period, had a greater than twofold likelihood of T2DM compared with that of unexposed controls. There was a dose-response relationship between severity of famine exposure and increase in adult T2DM risk.