Organizing the coactivity structure of the hippocampus from robust to flexible memory

• 成果类型: Article
• 署名作者: Gava, Giuseppe P.; Lefevre, Laura; Broadbelt, Tabitha; McHugh, Stephen B.; Lopes-dos-Santos, Vitor; Brizee, Demi; Hartwich, Katja; Sjoberg, Hanna; Perestenko, Pavel V.; Toth, Robert; Sharott, Andrew; Dupret, David
• 署名单位: UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Oxford
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13621
• DOI: 10.1126/science.adk9611
• 发表日期: 2024-09-06
• 页码: 1120-1127
• 关键词: network activity; pyramidal cells; DYNAMICS; deep; ORGANIZATION; neophobia; diversity; circuits; neurons; cortex

摘要

New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the mouse hippocampus within a population activity space of highly correlated spike trains that prevents subsequent computation of a flexible (object-location) memory. This densely correlated firing structure developed over repeated mnemonic experience, gradually coupling neurons in the superficial sublayer of the CA1 stratum pyramidale to whole-population activity. Applying hippocampal theta-driven closed-loop optogenetic suppression to mitigate this neuronal recruitment during (food-context) memory formation relaxed the topological constraint on hippocampal coactivity and restored subsequent flexible (object-location) memory. These findings uncover an organizational principle for the peer-to-peer coactivity structure of the hippocampal cell population to meet memory demands.