Serotonin release in the habenula during emotional contagion promotes resilience

• 成果类型: Article
• 署名作者: Mondoloni, Sarah; Molina, Patricia; Lecca, Salvatore; Wu, Cheng-Hsi; Michel, Leo; Osypenko, Denys; Cachin, Fanchon; Flanigan, Meghan; Congiu, Mauro; Lalive, Arnaud L.; Kash, Thomas; Deng, Fei; Li, Yulong; Mameli, Manuel
• 署名单位: University of Lausanne; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Peking University; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Norwegian University of Science & Technology (NTNU)
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11414
• DOI: 10.1126/science.adp3897
• 发表日期: 2024-09-06
• 页码: 1081-1086
• 关键词: lateral habenula; raphe nucleus; neurons; dorsal; inputs; DEPRESSION

摘要

Negative emotional contagion-witnessing others in distress-affects an individual's emotional responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice that briefly observe a conspecific being harmed become resilient, withstanding behavioral despair after an adverse experience. Photometric recordings during negative emotional contagion revealed increased serotonin (5-HT) release in the lateral habenula. Whereas 5-HT and emotional contagion reduced habenular burst firing, limiting 5-HT synthesis prevented burst plasticity. Enhancing raphe-to-habenula 5-HT was sufficient to recapitulate resilience. In contrast, reducing 5-HT release in the habenula made witnessing a conspecific in distress ineffective to promote the resilient phenotype after adversity. These findings reveal that 5-HT supports vicarious emotions and leads to resilience by tuning definite patterns of habenular neuronal activity.