Exploiting the mechanical effects of ultrasound for noninvasive therapy

• 成果类型: Review
• 署名作者: O'Reilly, Meaghan A.
• 署名单位: University of Toronto; Sunnybrook Research Institute; Sunnybrook Health Science Center; University of Toronto
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9957
• DOI: 10.1126/science.adp7206
• 发表日期: 2024-09-13
• 页码: 1179-+
• 关键词: blood-brain-barrier; transcranial focused ultrasound; boiling histotripsy; delivery; stimulation; cavitation; ablation; tumor; cancer; tau

摘要

Focused ultrasound is a platform technology capable of eliciting a wide range of biological responses with high spatial precision deep within the body. Although focused ultrasound is already in clinical use for focal thermal ablation of tissue, there has been a recent growth in development and translation of ultrasound-mediated nonthermal therapies. These approaches exploit the physical forces of ultrasound to produce a range of biological responses dependent on exposure conditions. This review discusses recent advances in four application areas that have seen particular growth and have immense clinical potential: brain drug delivery, neuromodulation, focal tissue destruction, and endogenous immune system activation. Owing to the maturation of transcranial ultrasound technology, the brain is a major target organ; however, clinical indications outside the brain are also discussed. with contrast agents that can amplify the ultrasound effects on the vasculature, is being used to disrupt tumors and generate a potent antitumor immune response. Combination therapies with immune checkpoint inhibitors and other immune adjuvants are also being explored to enhance the immune-simulating effects of ultrasound exposure.