Neurotoxic mixture effects of chemicals extracted from blood of pregnant women

• 成果类型: Article
• 署名作者: Braun, Georg; Herberth, Gunda; Krauss, Martin; Koenig, Maria; Wojtysiak, Niklas; Zenclussen, Ana C.; Escher, Beate I.
• 署名单位: Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Leipzig University; Eberhard Karls University of Tubingen
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10751
• DOI: 10.1126/science.adq0336
• 发表日期: 2024-10-18
• 关键词: organic pollutants pops; human relevant mixture; in-vivo extrapolation; partition-coefficients; neurite outgrowth; atopic-dermatitis; breast-milk; exposome; exposure; ACID

摘要

Human biomonitoring studies typically capture only a small and unknown fraction of the entire chemical universe. We combined chemical analysis with a high-throughput in vitro assay for neurotoxicity to capture complex mixtures of organic chemicals in blood. Plasma samples of 624 pregnant women from the German LiNA cohort were extracted with a nonselective extraction method for organic chemicals. 294 of >1000 target analytes were detected and quantified. Many of the detected chemicals as well as the whole extracts interfered with neurite development. Experimental testing of simulated complex mixtures of detected chemicals in the neurotoxicity assay confirmed additive mixture effects at concentrations less than individual chemicals' effect thresholds. The use of high-throughput target screening combined with bioassays has the potential to improve human biomonitoring and provide a new approach to including mixture effects in epidemiological studies.