Sensation is dispensable for the maturation of the vestibulo-ocular reflex

• 成果类型: Article
• 署名作者: Leary, Paige; Bellegarda, Celine; Quainoo, Cheryl; Goldblatt, Dena; Rosti, Basak; Schoppik, David
• 署名单位: New York University; New York University; New York University; New York University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8924
• DOI: 10.1126/science.adr9982
• 发表日期: 2025-01-03
• 页码: 85-90
• 关键词: zebrafish; behaviors; circuit; neurons; ear

摘要

Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. Development of the neuromuscular junction, and not sensory experience, therefore determines the rate of maturation of an ancient behavior.