Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis

• 成果类型: Article
• 署名作者: Ongaro, Luisina; Zhou, Xiang; Wang, Ying; Schultz, Hailey; Zhou, Ziyue; Buddle, Evan R. S.; Brule, Emilie; Lin, Yeu-Farn; Schang, Gauthier; Hagg, Adam; Castonguay, Roselyne; Liu, Yewei; Su, Gloria H.; Seidah, Nabil G.; Ray, Kevin C.; Karp, Seth J.; Boehm, Ulrich; Ruf-Zamojski, Frederique; Sealfon, Stuart C.; Walton, Kelly L.; Lee, Se-Jin; Bernard, Daniel J.
• 署名单位: McGill University; McGill University; University of Queensland; Jackson Laboratory; Columbia University; Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Vanderbilt University; Saarland University; Cedars Sinai Medical Center; Icahn School of Medicine at Mount Sinai; University of Connecticut
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9143
• DOI: 10.1126/science.adi4736
• 发表日期: 2025-01-17
• 页码: 329-336
• 关键词: differentiation factor-11; ii receptor; activin-b; beta; fsh; GROWTH; antagonism; inhibin; protein; follistatin

摘要

Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor-beta family, the activins. Our results both challenge activin's eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility.