Conserved brain-wide emergence of emotional response from sensory experience in humans and mice

• 成果类型: Article
• 署名作者: Kauvar, Isaac; Richman, Ethan B.; Liu, Tony X.; Li, Chelsea; Vesuna, Sam; Chibukhchyan, Adelaida; Yamada, Lisa; Fogarty, Adam; Solomon, Ethan; Choi, Eun Young; Mortazavi, Leili; Kung, Gustavo Chau Loo; Mukunda, Pavithra; Raja, Cephra; Gil-Hernandez, Dariana; Patron, Kishandra; Zhang, Xue; Brawer, Jacob; Wrobel, Shenandoah; Lusk, Zoe; Lyu, Dian; Mitra, Anish; Hack, Laura; Luo, Liqun; Grosenick, Logan; van Roessel, Peter; Williams, Leanne M.; Heifets, Boris D.; Henderson, Jaimie M.; McNab, Jennifer A.; Rodriguez, Carolyn I.; Buch, Vivek; Nuyujukian, Paul; Deisseroth, Karl
• 署名单位: Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System; Stanford University; Stanford University; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine; Stanford University; Stanford University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10510
• DOI: 10.1126/science.adt3971
• 发表日期: 2025-05-29
• 关键词: persistent activity; facial expressions; different forms; nmda receptors; power spectra; REGISTRATION; ketamine; robust; optimization; diffusion

摘要

Emotional responses to sensory experience are central to the human condition in health and disease. We hypothesized that principles governing the emergence of emotion from sensation might be discoverable through their conservation across the mammalian lineage. We therefore designed a cross-species neural activity screen, applicable to humans and mice, combining precise affective behavioral measurements, clinical medication administration, and brain-wide intracranial electrophysiology. This screen revealed conserved biphasic dynamics in which emotionally salient sensory signals are swiftly broadcast throughout the brain and followed by a characteristic persistent activity pattern. Medication-based interventions that selectively blocked persistent dynamics while preserving fast broadcast selectively inhibited emotional responses in humans and mice. Mammalian emotion appears to emerge as a specifically distributed neural context, driven by persistent dynamics and shaped by a global intrinsic timescale.