Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

• 成果类型: Article
• 署名作者: Yu, Xiaotong; Hu, Yanan; Lim, Hwee Ying; Li, Ziyi; Jaitin, Diego Adhemar; Yang, Katharine; Kong, Wan Ting; Xu, Jiaqian; Bejarano, David Alejandro; Bied, Mathilde; Orliaguet, Lucie; Rengasamy, Gowshika; Chow, Zachary; Lee, Christopher Zhe Wei; Lum, Josephine; Tian, Jing; Zhang, Xiao-Meng; Liu, Honghao; Tan, Shu Wen; Chen, Jinmiao; See, Peter; Loh, Yuin-Han; Malleret, Benoit; Baig, Sonia; Yassin, M. Shabeer M.; Toh, Sue-Anne Ee Shiow; Malissen, Bernard; Fu, Xiujun; Kabashima, Kenji; Ng, Lai Guan; Bleriot, Camille; Liu, Zhaoyuan; Sheng, Lingling; Zheng, Dan-Ning; Qu, Junwen; Venteclef, Nicolas; Su, Bing; Amit, Ido; Schlitzer, Andreas; Angeli, Veronique; Ginhoux, Florent; Chakarov, Svetoslav
• 署名单位: Shanghai Jiao Tong University; Chinese Academy of Sciences; National University of Singapore; National University of Singapore; Weizmann Institute of Science; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); UNICANCER; Gustave Roussy; University of Bonn; Universite Paris Cite; Agency for Science Technology & Research (A*STAR); Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); National University of Singapore; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Aix-Marseille Universite; Shanghai Jiao Tong University; Kyoto University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Central South University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12574
• DOI: 10.1126/science.adg1128
• 发表日期: 2025-08-28
• 关键词: brown adipose-tissue; local proliferation; mass cytometry; obesity; fat; contributes; modulation; expression; DYNAMICS; distinct

摘要

Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct localization, turnover, and phenotypes. Septal adipose tissue macrophages (sATMs), marked by CD209b and lymphatic vessel endothelial hyaluronan receptor 1, were long-lived and positioned in close proximity to adipocyte stem cells (ASCs) within the WAT septum. Within this shared niche, sATMs instructed the differentiation of ASCs into white adipocytes through transforming growth factor-beta 1 (TGF beta 1). Depletion of sATMs, or the selective loss of TGF beta 1 within tissue-resident macrophages, redirected ASC fate toward thermogenic adipocytes, enhancing WAT beiging and protecting against diet-induced obesity. These findings highlight the role of a discrete, anatomically defined macrophage population that governs ASC fate and orchestrates adipose tissue expansion.