Motor neurons generate pose-targeted movements via proprioceptive sculpting

• 成果类型: Article
• 署名作者: Gorko, Benjamin; Siwanowicz, Igor; Close, Kari; Christoforou, Christina; Hibbard, Karen L.; Kabra, Mayank; Lee, Allen; Park, Jin-Yong; Li, Si Ying; Chen, Alex B.; Namiki, Shigehiro; Chen, Chenghao; Tuthill, John C.; Bock, Davi D.; Rouault, Herve; Branson, Kristin; Ihrke, Gudrun; Huston, Stephen J.
• 署名单位: Howard Hughes Medical Institute; University of California System; University of California Santa Barbara; Johns Hopkins University; Harvard University; Harvard Medical School; University of Tokyo; University of Washington; University of Washington Seattle; University of Vermont; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Aix-Marseille Universite; Universite de Toulon; Columbia University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5928
• DOI: 10.1038/s41586-024-07222-5
• 发表日期: 2024-04-18
• 页码: 596-603
• 关键词: fly calliphora-erythrocephala; optic flow; motion; microstimulation; posture; SYSTEM; integration; drosophila; position; vision

摘要

Motor neurons are the final common pathway1 through which the brain controls movement of the body, forming the basic elements from which all movement is composed. Yet how a single motor neuron contributes to control during natural movement remains unclear. Here we anatomically and functionally characterize the individual roles of the motor neurons that control head movement in the fly, Drosophila melanogaster. Counterintuitively, we find that activity in a single motor neuron rotates the head in different directions, depending on the starting posture of the head, such that the head converges towards a pose determined by the identity of the stimulated motor neuron. A feedback model predicts that this convergent behaviour results from motor neuron drive interacting with proprioceptive feedback. We identify and genetically2 suppress a single class of proprioceptive neuron3 that changes the motor neuron-induced convergence as predicted by the feedback model. These data suggest a framework for how the brain controls movements: instead of directly generating movement in a given direction by activating a fixed set of motor neurons, the brain controls movements by adding bias to a continuing proprioceptive-motor loop. Single motor neurons in Drosophila are stimulated to show that they direct head movements towards specific postures rather than generating fixed movement vectors, suggesting that the brain controls movements through a continuing proprioceptive-motor loop.