The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
成果类型：
Article
署名作者：
Overbey, Eliah G.; Kim, JangKeun; Tierney, Braden T.; Park, Jiwoon; Houerbi, Nadia; Lucaci, Alexander G.; Medina, Sebastian Garcia; Damle, Namita; Najjar, Deena; Grigorev, Kirill; Afshin, Evan E.; Ryon, Krista A.; Sienkiewicz, Karolina; Patras, Laura; Klotz, Remi; Ortiz, Veronica; MacKay, Matthew; Schweickart, Annalise; Chin, Christopher R.; Sierra, Maria A.; Valenzuela, Matias F.; Dantas, Ezequiel; Nelson, Theodore M.; Cekanaviciute, Egle; Deards, Gabriel; Foox, Jonathan; Narayanan, S. Anand; Schmidt, Caleb M.; Schmidt, Michael A.; Schmidt, Julian C.; Mullane, Sean; Tigchelaar, Seth Stravers; Levitte, Steven; Westover, Craig; Bhattacharya, Chandrima; Lucotti, Serena; Hirschberg, Jeremy Wain; Proszynski, Jacqueline; Burke, Marissa; Kleinman, Ashley S.; Butler, Daniel J.; Loy, Conor; Mzava, Omary; Lenz, Joan; Paul, Doru; Mozsary, Christopher; Sanders, Lauren M.; Taylor, Lynn E.; Patel, Chintan O.; Khan, Sharib A.; Mohamad, Mir Suhail; Byhaqui, Syed Gufran Ahmad; Aslam, Burhan; Gajadhar, Aaron S.; Williamson, Lucy; Tandel, Purvi; Yang, Qiu; Chu, Jessica; Benz, Ryan W.; Siddiqui, Asim; Hornburg, Daniel; Blease, Kelly; Moreno, Juan; Boddicker, Andrew; Zhao, Junhua; Lajoie, Bryan; Scott, Ryan T.; Gilbert, Rachel R.; Polo, San-huei Lai; Altomare, Andrew; Kruglyak, Semyon; Levy, Shawn; Ariyapala, Ishara; Beer, Joanne; Zhang, Bingqing; Hudson, Briana M.; Rininger, Aric; Church, Sarah E.; Beheshti, Afshin; Church, George M.; Smith, Scott M.; Crucian, Brian E.; Zwart, Sara R.; Matei, Irina; Lyden, David C.; Garrett-Bakelman, Francine; Krumsiek, Jan; Chen, Qiuying; Miller, Dawson; Shuga, Joe; Williams, Stephen; Nemec, Corey; Trudel, Guy; Pelchat, Martin; Laneuville, Odette; De Vlaminck, Iwijn; Gross, Steven; Bolton, Kelly L.; Bailey, Susan M.; Granstein, Richard; Furman, David; Melnick, Ari M.; Costes, Sylvain V.; Shirah, Bader; Yu, Min; Menon, Anil S.; Mateus, Jaime; Meydan, Cem; Mason, Christopher E.
署名单位：
Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Babes Bolyai University from Cluj; University of Southern California; Buck Institute for Research on Aging; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Columbia University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; State University System of Florida; Florida State University; Colorado State University System; Colorado State University Fort Collins; SpaceX; Stanford University; Houston Methodist; Cornell University; Cornell University; Weill Cornell Medicine; Colorado State University System; Colorado State University Fort Collins; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; NanoString Technologies; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; University of Texas System; University of Texas Medical Branch Galveston; University of Virginia; University of Virginia; Cornell University; Weill Cornell Medicine; University of Ottawa; Ottawa Hospital Research Institute; University of Ottawa; Ottawa Hospital Research Institute; University of Ottawa; University of Ottawa; University of Ottawa; Washington University (WUSTL); Colorado State University System; Colorado State University Fort Collins; Cornell University; Weill Cornell Medicine; Stanford University; Austral University; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); King Faisal Specialist Hospital & Research Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
刊物名称：
Nature
ISSN/ISSBN：
0028-4713
DOI：
10.1038/s41586-024-07639-y
发表日期：
2024-08-29
页码：
1145-+
关键词：
摘要：
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space(1-6). Yet current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools and protocols. Here we present the Space Omics and Medical Atlas (SOMA), an integrated data and sample repository for clinical, cellular and multi-omic research profiles from a diverse range of missions, including the NASA Twins Study(7), JAXA CFE study(8,9), SpaceX Inspiration4 crew(10-12), Axiom and Polaris. The SOMA resource represents a more than tenfold increase in publicly available human space omics data, with matched samples available from the Cornell Aerospace Medicine Biobank. The Atlas includes extensive molecular and physiological profiles encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics and microbiome datasets, which reveal some consistent features across missions, including cytokine shifts, telomere elongation and gene expression changes, as well as mission-specific molecular responses and links to orthologous, tissue-specific mouse datasets. Leveraging the datasets, tools and resources in SOMA can help to accelerate precision aerospace medicine, bringing needed health monitoring, risk mitigation and countermeasure data for upcoming lunar, Mars and exploration-class missions.