全球经管学术

成果类型：

Review

署名作者：

Case, Nicola T.; Gurr, Sarah J.; Fisher, Matthew C.; Blehert, David S.; Boone, Charles; Casadevall, Arturo; Chowdhary, Anuradha; Cuomo, Christina A.; Currie, Cameron R.; Denning, David W.; Ene, Iuliana V.; Fritz-Laylin, Lillian K.; Gerstein, Aleeza C.; Gow, Neil A. R.; Gusa, Asiya; Iliev, Iliyan D.; James, Timothy Y.; Jin, Hailing; Kahmann, Regine; Klein, Bruce S.; Kronstad, James W.; Ost, Kyla S.; Peay, Kabir G.; Shapiro, Rebecca S.; Sheppard, Donald C.; Shlezinger, Neta; Stajich, Jason E.; Stukenbrock, Eva H.; Taylor, John W.; Wright, Gerard D.; Cowen, Leah E.; Heitman, Joseph; Segre, Julia A.

署名单位：

University of Toronto; University of Exeter; Utrecht University; Imperial College London; United States Department of the Interior; United States Geological Survey; University of Toronto; RIKEN; Johns Hopkins University; University of Delhi; University of Delhi; Brown University; McMaster University; University of Wisconsin System; University of Wisconsin Madison; University of Manchester; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Massachusetts System; University of Massachusetts Amherst; University of Manitoba; University of Manitoba; University of Exeter; Duke University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Michigan System; University of Michigan; University of California System; University of California Riverside; Max Planck Society; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of British Columbia; University of Colorado System; University of Colorado Anschutz Medical Campus; Stanford University; Stanford University; University of Guelph; McGill University; McGill University; Hebrew University of Jerusalem; University of Kiel; Max Planck Society; University of California System; University of California Berkeley; McMaster University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)

刊物名称：

Nature

ISSN/ISSBN：

0028-3539

DOI：

10.1038/s41586-024-08419-4

发表日期：

2025-02-05

页码：

49-57

关键词：

biological-control emerging fungal food security small rnas plant diversity emergence immunity disease gut

摘要：

Over the past billion years, the fungal kingdom has diversified to more than two million species, with over 95% still undescribed. Beyond the well-known macroscopic mushrooms and microscopic yeast, fungi are heterotrophs that feed on almost any organic carbon, recycling nutrients through the decay of dead plants and animals and sequestering carbon into Earth's ecosystems. Human-directed applications of fungi extend from leavened bread, alcoholic beverages and biofuels to pharmaceuticals, including antibiotics and psychoactive compounds. Conversely, fungal infections pose risks to ecosystems ranging from crops to wildlife to humans; these risks are driven, in part, by human and animal movement, and might be accelerating with climate change. Genomic surveys are expanding our knowledge of the true biodiversity of the fungal kingdom, and genome-editing tools make it possible to imagine harnessing these organisms to fuel the bioeconomy. Here, we examine the fungal threats facing civilization and investigate opportunities to use fungi to combat these threats.

Fungal impacts on Earth's ecosystems