A kinase mediator of rhizobial symbiosis and immunity in Medicago

• 成果类型: Article
• 署名作者: Wang, Dapeng; Jin, Rui; Shi, Xiaobao; Guo, Haoran; Tan, Xinhang; Zhao, Achen; Lian, Xinghua; Dai, Huiling; Li, Shaozhuang; Xin, Kexu; Tian, Changfu; Yang, Jun; Chen, Wansheng; Macho, Alberto P.; Wang, Ertao
• 署名单位: Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Shanghai University of Traditional Chinese Medicine; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; China Agricultural University; ShanghaiTech University
• 刊物名称: Nature
• ISSN/ISSBN: 0028-2443
• DOI: 10.1038/s41586-025-09057-0
• 发表日期: 2025-07-17
• 关键词: plant innate immunity; receptor kinase; lysm domains; truncatula; perception; gene; agrobacterium; peptidoglycan; localization; accumulation

摘要

Legume roots secure nitrogen by forming a symbiosis with soil rhizobia but remain resistant to pathogenic bacteria1, 2, 3-4. How this tolerance to rhizobia is achieved without compromising plant immunity is largely unknown. Here we identify the cytoplasmic kinase MtLICK1/2, which interacts with nodulation factor receptor MtLYK3 to drive symbiotic signalling and suppress plant immunity. Rhizobial infection and nodule development are defective in Mtlick1/2, phenocopying the Mtlyk3-1 mutant. MtLICK1/2 and MtLYK3 undergo reciprocal transphosphorylation during rhizobial symbiosis. Phosphorylated MtLYK3 activates the receptor-like kinase MtDMI2 to stimulate symbiotic signalling. MtLICK1/2 is activated in the rhizobial infection area to suppress plant immunity. Thus, MtLICK1/2 and MtLYK3 together amplify symbiotic signalling and dampen host immunity to enable legume-rhizobium symbiosis.